Endocrine Abstracts

Introduction: Long term remission of CD is achieved in 65–83% after neurosurgery, while the remaining cases have recurrence or continued tumor growth. This paper deals with the problem of CD prognostic factors after neurosurgery.Design: ACTH and cortisol blood levels, free cortisol in daily urine, MRI, histology (hemotaxiline–eosine staining) and immunohistochemistry (with antibodies to the pituitary tropic hormones, Ki-67, CD31 and VEGF) of th...

In ESC for the period since October 2004 till October 2006 were operated 69 patients with acromegaly. Men were 22 (32%), women – 47 (68%). Age of patients changed from 24 till 68 (middle – 47).All patients were separated into 2 groups: surgery (group 1) and combination treatment (group 2), which consist of surgery and somatostatin analogues therapy before and after surgery.In most cases were macroadenomas, only 5 patients...

In our study we included retrospective analyses of 101 patients (mean age 35 years, 85 women and 16 men) with Cushing’s disease (CD), who underwent transsphenoidal surgery (TSS) treatment. CD is based on clinical suspicion, hormonal research of cortisol (F), ACTH, 24-hous urine F, results of dexamethasone suppression tests low (1 mg) dose (LDDST) and high (8 mg) dose (HDDST) and MR-imaging (MRI). Before the operation all patients have high F, ACTH, negative LDDST and posi...

Coexistence of different types of brain tumors is a very rare condition. We present a clinical case of PRL-secreting adenoma and germ cell tumor coexistence in 14-year-old adolescent. The patient was admitted to our Center with complaints of headache with nausea episodes, left-sided ptosis. Visual acuity was: visus OD=1.0; visus OS=0.6 Cyl -0.5 ax 70=1.0. Neuroimaging revealed supra-para(D,S) sellar mass 39×32×21 mm. Laboratory data revealed hypothyroidism, hypocorti...

Cushing’s disease (CD) remission after primary surgical treatment is achieved in 70–90%, but recurrence ranges 18–25% after.The aim of this work was to study clinical, hormonal and MRI indicators before and after surgical treatment in patients with recurrent CD to identify possible predictors of recurrence. We examined 49 patients with recurrent CD in the active stage (disease duration up to 3 years). Before neurosurgery blood ACTH (median...

Phaeochromocytomas are responsible for the development ACTH-ectopic syndrome in 5% cases. Less than 1% phaeochromocytoma accompanied by symptoms of ACTH-dependent hypercortisolism. We observed four cases of ACTH-secreting phaeochromocytoma during 2 years. All patients were women from 50 to 63 years. The disease duration ranged from 6 months to 5 years. The clinical picture presented the signs of hypercortisolism (matronism, hyperpigmentation of the skin, the redistribution of ...

Backgraund: The high incidence of cervical lymph nodes (LNs) metastasis in differentiated thyroid carcinoma (DTC) and lack of effective diagnostic tools determines the need for elaboration more specific tests.Aims: The aim of our study was to evaluate the accuracy and cut-off point of the thyroglobulin (Tg) in the washout fluid of fine-needle aspiration biopsy (FNA-Tg) in the diagnosis of DTC LNs metastasis.Materials and methods: A...

Introduction: This study evaluates the diagnostic accuracy of clinical features and first line routine screening tests to differentiate ACTH-ectopic syndrome from Cushing’s disease (CD).Materials and methods: The retrospective clinical and biochemical presentations of 180 patients with histologically proven ACTH-dependent Cushing’s syndrome (CS) (159 CD, 21 ACTH-ectopic syndrome) were compared according to the cause of hypercortisolism. ROC-ana...

Objectives: To assess prevalence of antipsychotic-induced hyperpolactinemia (AIH) in psychiatric in-patients and to describe its clinical characteristics and association of AIH with sexual function.Methods: A cross-sectional study in 143 consecutive psychiatric in-patients (F/M=65/78), mostly with schizophrenia (93%), currently taking antipsychotics. The patients were screened for serum prolactin, sex hormones, gonadotropin levels and macroprolactin. For...

The study analyses direct postoperative and long-term results of surgical treatment of ACTH-secreting pituitary adenomas in 158 patients, operated between 2004 and 2009. There were 143 (91%) female and 15 (9%) male. The mean age of the patients was 36 years, S.D. 10.7. In all patients the diagnosis of Cushing’s disease was confirmed by high dose dexamethasone suppression test. Preoperative hormonal evaluation: ACTH (0800 h), pg/ml (Me-78.5 (50.5 (25th perce...